CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 100 enrolled
Drug / intervention
Impact of Killing (IOK) +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03764033
NCT03764033N/ACompleted

A Novel Posttraumatic Stress Disorder Treatment for Veterans With Moral Injury

VA Office of Research and Development·interventional·Posted Dec 4, 2018·Updated Nov 20, 2025

In Brief

A clinical study evaluating Impact of Killing (IOK) and Present Centered Therapy for Moral Injury. Completed, enrolled 100 participants across 3 sites.

Detailed Summary

The objective of this project is to test the efficacy of an individual treatment for post-traumatic stress disorder (PTSD) stemming from moral injury called Impact of Killing (IOK), compared to a present-centered therapy (PCT) control condition, and to determine the rehabilitative utility of IOK for Veterans with PTSD. The first aim is to test whether IOK can help improve psychosocial functioning for Veterans, as well as PTSD symptoms. The second aim is to determine whether IOK gains made by Veterans in treatment are durable, as measured by a six-month follow-up assessment. Veterans who kill in war are at increased risk for functional difficulties, PTSD, alcohol abuse, and suicide. Even after current PTSD psychotherapies, most Veterans continue to meet diagnostic criteria for PTSD, highlighting the need for expanding treatments for PTSD and functioning. IOK is a treatment that can be provided following existing PTSD treatments, filling a critical gap for Veterans with moral injury who continue to suffer from mental health symptoms and functional difficulties.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMoral Injury
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
20192020202120222023202420252026
First PostedDec 4, 2018
Enrollment StartAug 12, 2019
Primary CompletionNov 15, 2024
Study CompletionDec 31, 2024
TodayJul 2, 2026
Enrollment to primary: 5.3 yearsPosted 7.6 years ago

Interventions

Impact of Killing (IOK)behavioral

Participants in this arm will receive 10 sessions (60-90 minutes) of a cognitive-behavioral moral injury treatment called IOK .

Present Centered Therapybehavioral

Participants in this arm will receive 10 sessions (60-90 minutes) of a PTSD treatment that does not focus on trauma or cognitive restructuring, but rather the functional impact of trauma called Present Center Therapy (PCT)