At a glance
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Multimodal Assessment of Dyspnea, Cardiopulmonary Structure and Function in Chronic Hemodialysis Patients
In Brief
An observational study evaluating Lung MRI, Sodium MRI, and 7 other interventions for Dyspnea; Uremic and 5 related conditions. Completed, enrolled 7 participants across 1 site.
Detailed Summary
Shortness of breath is very common among patients on dialysis for kidney failure; however, its causes are often not understood. This study will explore the lungs and the heart of these patients to determine the causes of shortness of breath. The amount of salt in the body tissues, which tends to accumulate in dialysis patients and can also cause shortness of breath, will also be measured. Machines that exploit magnetic resonance, ultrasound and x-rays to take images of the body interior will be employed; in addition, breathing tests, questionnaires and blood tests will also be used. 20 patients on dialysis will be recruited and have two visits: one at the beginning of the study and one year later to observe any changes in the lungs, heart and salt accumulation over time.
Study Details
Timeline
Interventions
Proton Lung Magnetic Resonance Imaging
Sodium Soft Tissue Magnetic Resonance Imaging
High-resolution Quantitative Chest CT
Transthoracic 2D Speckle-Tracking Echocardiography
Fractional Exhaled Nitric Oxide testing
Spirometry and Plethysmography
Blood testing for: standard-of-care, inflammatory biomarkers, uremic toxins
Six-Minute Walk Test
Modified Medical Research Council; University of California, San Diego Shortness of Breath Questionnaire; Borg Scale