At a glance

ClinicalIndex Comparison Record

N/ACompleted· 15 enrolled

Drug / intervention

Sugar drinkother

Likely dose

Not stated in record

Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03783195

NCT03783195N/ACompleted

Compare CT.gov

Genetic-specific Effects of Fructose on Liver Lipogenesis

University of North Carolina, Chapel Hill·interventional·Posted Dec 20, 2018·Updated Oct 23, 2024

In Brief

A clinical study evaluating Sugar drink for NAFLD. Completed, enrolled 15 participants across 1 site.

Detailed Summary

The primary goal of this study is to identify a set of genotypes that increase the risk for nonalcoholic fatty liver disease (NAFLD) and predispose individuals to increased de novo lipogenesis (DNL) and liver fat accumulation when exposed to fructose intake. The proposed goal will be achieved through the completion of following aims: 1. To determine the impact of prolonged exposure of fructose on hepatic lipid accumulation in Caucasian individuals with high and low genetic risk for NAFLD, 2. to determine the impact of acute exposure of fructose on hepatic DNL, and 3. to determine the relationship between markers of DNL, liver fat accumulation and serum concentrations of lipids, uric acid and liver function markers before and after the fructose challenge.

Study Details

Study Typeinterventional

Allocation--

Masking--

Primary Purpose--

ConditionsNAFLD

CountriesUnited States

CollaboratorsNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Timeline

N/ACompletedFinished

20192020202120222023202420252026

First PostedDec 2018

Enrollment StartJan 2019

Primary CompletionApr 2023

TodayJul 2026

First PostedDec 20, 2018

Enrollment StartJan 25, 2019

Primary CompletionApr 25, 2023

TodayJul 2, 2026

Enrollment to primary: 4.3 yearsPosted 7.5 years ago

Interventions

Sugar drinkother

A sugar drink made with 1.2 g/kg body weight of added sugar( 0.75g/kg body weight of fructose + 0.45g/kg body weight of glucose) and 24oz water