CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 72 enrolled
Drug / intervention
practice of a complex walking task +2 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03790657
NCT03790657Phase 1Completed

Cerebral Networks of Locomotor Learning and Retention in Older Adults

VA Office of Research and Development·interventional·Posted Dec 31, 2018·Updated Sep 22, 2025

In Brief

A Phase 1 clinical trial evaluating practice of a complex walking task, Active transcranial direct current stimulation (Active tDCS), and 1 other intervention for Aging. Completed, enrolled 72 participants across 1 site.

Detailed Summary

Older adults often experience substantial deficits in walking ability, especially for walking tasks that are more complex such as obstacle crossing. This is due in part to changes in the brain that make performance of physical and cognitive tasks more difficult. Rehabilitation can help to improve walking ability, but effective rehabilitation is time consuming and expensive. New approaches are needed to improve the efficiency of rehabilitation so that gains in walking ability are widely attainable. A promising strategy is to focus on enhancing motor learning, which is defined as improved ability to perform a motor task due to practice or experience. The investigators will investigate the use of non-invasive brain stimulation to increase motor learning and retention of the newly learned walking skills. The investigators will also use neuroimaging to assess brain characteristics that explain how motor learning works. The knowledge gained from this study is expected to contribute to better understanding of mechanistic targets and intervention approaches to improve rehabilitation of walking.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAging
CountriesUnited States
Collaborators--

Timeline

Phase 1CompletedFinished
20192020202120222023202420252026
First PostedDec 31, 2018
Enrollment StartAug 1, 2019
Primary CompletionAug 1, 2024
TodayJul 2, 2026
Enrollment to primary: 5 yearsPosted 7.5 years ago

Interventions

practice of a complex walking taskbehavioral

walking over obstacles

Active transcranial direct current stimulation (Active tDCS)device

mild electrical stimulation delivered to the frontal region of the brain

Sham transcranial direct current stimulation (Sham tDCS)device

30 seconds of mild electrical stimulation delivered to the frontal region of the brain