CI

At a glance

ClinicalIndex Comparison Record
Early Ph 1Completed· 7 enrolled
Drug / intervention
[14C]-benzo[a]pyrene +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03802721
NCT03802721Early Ph 1Completed
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Pharmacokinetics of Benzo[a]Pyrene: Impact of Diet

Oregon State University·interventional·Posted Jan 14, 2019·Updated Jun 22, 2025

In Brief

A Early Phase 1 clinical trial evaluating [14C]-benzo[a]pyrene, Brussels sprouts before 50 ng dose, and 1 other intervention for Environmental Exposure. Completed, enrolled 7 participants across 1 site.

Detailed Summary

Evaluation of the pharmacokinetics for \[14C\]-benzo\[a\]pyrene (\[14C\]-BaP) and metabolites in plasma and urine over 48 hours following a 50 ng dose (5.4 nCi) alone, following 7 days' consumption of Brussels sprouts, and following 7 days' consumption of a supplement containing 3,3'-diindolylmethane (DIM).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsEnvironmental Exposure
CountriesUnited States
CollaboratorsNational Institute of Environmental Health Sciences (NIEHS), Lawrence Livermore National Laboratory, Pacific Northwest National Laboratory

Timeline

Early Ph 1CompletedFinished
20192020202120222023202420252026
First PostedJan 14, 2019
Enrollment StartJan 24, 2019
Primary CompletionJan 1, 2024
Study CompletionFeb 1, 2024
TodayJul 2, 2026
Enrollment to primary: 4.9 yearsPosted 7.5 years ago

Interventions

[14C]-benzo[a]pyrenedrug

Oral micro-dose (50 ng) (5.4 nCi)

Brussels sprouts before 50 ng dosedrug

Brussels sprouts for 7 days before 50 ng (5.4 nCi) dose of BaP

DIM supplement before 50 ng dosedrug

DIM supplement for 7 days before 50 ng (5.4 nCi) dose of BaP and coadministration with DIM supplement