CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 103 enrolled
Drug / intervention
End-expiratory occlusion test (EEOT) +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03808753
NCT03808753N/ACompleted
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Mini Fluid chAlleNge and End-expiratory Occlusion Test and to Assess flUid responsiVEness in opeRating Room: an Open-label, Randomized Clinical Trial

Humanitas Clinical and Research Center·interventional·Posted Jan 18, 2019·Updated Jan 18, 2020

In Brief

A clinical study evaluating End-expiratory occlusion test (EEOT) and mini fluid challenge (mFC) for Hemodynamic Instability and 2 related conditions. Completed, enrolled 103 participants across 3 sites.

Detailed Summary

End-expiratory occlusion test (EEOT) has been previously successfully tested in surgical patients, consisting of the interruption of the mechanical ventilation for 30 seconds, and in the evaluation of the changes in the SV. The mini fluid challenge test (mFC) aims at testing the increase in SV after the rapid administration of a small aliquot of the predefined FC. Both these test have been previously evaluated in small-sized studies and never compared each other.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHemodynamic Instability, Anesthesia, Surgery
CountriesItaly
Collaborators--

Timeline

N/ACompletedFinished
20192020202120222023202420252026
First PostedJan 18, 2019
Enrollment StartFeb 27, 2019
Primary CompletionJan 16, 2020
TodayJul 2, 2026
Enrollment to primary: 11 monthsPosted 7.5 years ago

Interventions

End-expiratory occlusion test (EEOT)other

The EEOT is performed by interrupting the mechanical ventilation for 30 seconds, by using and end-expiratory hold on the ventilator.

mini fluid challenge (mFC)other

The mFC is performed by injecting a first aliquot of 100 ml of crystalloid over 1 minute before completing the 4 ml/kg-FC over the residual 9 minutes.