At a glance
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Multimodal Analysis and Electroretinogram in VKH From Acute Onset - a Prospective Study
In Brief
A clinical study evaluating Corticosteroid monotherapy for Uveomeningoencephalitic Syndrome and 3 related conditions. Completed, enrolled 12 participants across 1 site.
Detailed Summary
Patients with acute onset Vogt-Koyanagi-Harada disease (VKHD) were prospectively included in this study. They were systematically followed with clinical, posterior segment imaging exams and full-field electroretinogram during a minimum 24-month of follow-up. All patients were treated with 3-day methylprednisolone pulse therapy followed by 1mg/day oral prednisone with a slow tapper during a median of 13 months. Non-steroidal immunosuppressive therapy (IMT) was introduced in cases of refractory disease or in cases of prednisone intolerance. Outcome measured by full-field electroretinogram was analyzed and patient was grouped as electroretinogram stable or electroretinogram worsening. Clinical data was analyzed in these two electroretinogram-based groups.
Study Details
Timeline
Interventions
Patients will receive corticosteroid monotherapy as a pulsetherapy (1000mg/ day for 3 days) followed by oral corticosteroid.