At a glance
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Aspirin for Exercise in Multiple Sclerosis (ASPIRE): A Double-Blind RCT of Aspirin or Acetaminophen Pretreatment to Improve Exercise Performance in Multiple Sclerosis (MS)
In Brief
A Phase 3 clinical trial evaluating Aspirin 650mg Oral Capsule, Acetaminophen Tablet 650mg, and 1 other intervention for Multiple Sclerosis. Completed, enrolled 60 participants across 1 site.
Detailed Summary
This study investigates the use of aspirin as an exercise pre-treatment to reduce overheating and exhaustion, which may potentially allow many more people with multiple sclerosis to participate in and benefit from exercise. The design is double-blind, within-subject, with three arms: participants will receive one of three treatments at three separate study visits: aspirin, acetaminophen, and placebo, followed by completion of a maximal exercise test.
Study Details
Timeline
Interventions
A 650mg dose of aspirin is administered in the laboratory one hour before participant completes a maximal exercise test.
A 650mg dose of acetaminophen is administered in the laboratory one hour before participant completes a maximal exercise test.
A placebo pill is administered in the laboratory one hour before participant completes a maximal exercise test.