At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
TRANScranial Direct Current Stimulation for POst-stroke Motor Recovery - a Phase II sTudy (TRANSPORT 2)
In Brief
A Phase 2 clinical trial evaluating Sham, Low dose tDCS, and 2 other interventions for Stroke, Ischemic and 2 related conditions. Completed, enrolled 129 participants across 14 sites.
Detailed Summary
This research study is to find out if brain stimulation at different dosage level combined with an efficacy-proven rehabilitation therapy can improve arm function. The stimulation technique is called transcranial direct current stimulation (tDCS). The treatment uses direct currents to stimulate specific parts of the brain affected by stroke. The adjunctive rehabilitation therapy is called "modified Constraint-Induced Movement Therapy" (mCIMT). During this therapy the subject will wear a mitt on the hand of the arm that was not affected by a stroke and force to use the weak arm. The study will test 3 different doses of brain stimulation in combination with mCIMT to find out the most promising one.
Study Details
Timeline
Interventions
Sham group only receives 30 seconds of stimulation at 2mA in the beginning to create a sensory perception to the scalp in order to blind the subject.
The low dose tDCS group receives direct current stimulation at 2 mA for 30 minutes per session
The high dose tDCS group receives direct current stimulation at 4 mA for 30 minutes per session
All three tDCS groups receive constraint-induced movement therapy as the adjunctive behavioral therapy for 2 hours per session