CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 268 enrolled
Drug / intervention
REBOOTbehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03838510
NCT03838510N/ACompleted
CompareCT.gov

Repeated-dose Behavioral Intervention to Reduce Opioid Overdose: A Two-Site Randomized-Controlled Efficacy Trial (REBOOT)

San Francisco Department of Public Health·interventional·Posted Feb 12, 2019·Updated Jun 15, 2025

In Brief

A clinical study evaluating REBOOT for Opioid-Related Disorders and Drug Overdose. Completed, enrolled 268 participants across 2 sites.

Detailed Summary

REBOOT is a randomized trial of a repeated-dose brief intervention to reduce overdose and risk behaviors among naloxone recipients with opioid use disorder. It includes an established overdose education curriculum within an Informational-Motivation-Behavior (IMB) model. This study will test the efficacy of REBOOT vs attention-control.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsOpioid-Related Disorders, Drug Overdose
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
20192020202120222023202420252026
First PostedFeb 12, 2019
Enrollment StartApr 22, 2019
Primary CompletionDec 12, 2023
TodayJul 2, 2026
Enrollment to primary: 4.6 yearsPosted 7.4 years ago

Interventions

REBOOTbehavioral

The brief counseling intervention will utilize Motivational Interviewing and skills-building techniques to modify personal overdose risk behaviors and develop skills as a peer responder for witnessed overdose. The counselor will draw upon themes of safer substance use to address overdose risk behaviors and determine readiness for change in substance use.