CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 25 enrolled
Drug / intervention
Repetitive Transcranial Magnetic Stimulation to Right Dorsolateral Prefrontal Cortex +2 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03840369
NCT03840369N/ACompleted
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Pathophysiological Understanding and Treatment of PTSD: an rTMS Approach

University of Calgary·interventional·Posted Feb 15, 2019·Updated Nov 4, 2022

In Brief

A clinical study evaluating Repetitive Transcranial Magnetic Stimulation to Right Dorsolateral Prefrontal Cortex, Sham Repetitive Transcranial Magnetic Stimulation, and 1 other intervention for Stress Disorders, Post-Traumatic and 5 related conditions. Completed, enrolled 25 participants across 1 site.

Detailed Summary

In Canada, the prevalence of PTSD is approximately 12%, similar to Canadian military personnel. Current treatments for PTSD are limited in efficacy and durability - indicating a dire need for novel interventions in this population. Transcranial magnetic stimulation (TMS) has a high degree of safety and has been studied as an intervention for many mental health and neurological conditions; even showing initial promise for PTSD. We propose to study this further in a randomized sham controlled trial of TMS for PTSD.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsStress Disorders, Post-Traumatic, Brain Injuries, Transcranial Magnetic Stimulation, Magnetic Resonance Spectroscopy, Biomarkers, Depression, Anxiety
CountriesCanada
CollaboratorsDefence Research and Development Canada

Timeline

N/ACompletedFinished
20192020202120222023202420252026
First PostedFeb 15, 2019
Enrollment StartJun 1, 2020
Primary CompletionFeb 18, 2022
Study CompletionMar 18, 2022
TodayJul 2, 2026
Enrollment to primary: 1.7 yearsPosted 7.4 years ago

Interventions

Repetitive Transcranial Magnetic Stimulation to Right Dorsolateral Prefrontal Cortexdevice

Transcranial magnetic stimulation (TMS) works by delivering a magnetic pulse to a focal brain region. TMS has a high degree of safety and has been studied as an intervention for many mental health and neurological conditions. Repetitive TMS (rTMS) delivers pulses at a set time interval in order to modulate neural activity in that region.

Sham Repetitive Transcranial Magnetic Stimulationdevice

The sham TMS coil will make a similar sound to the real rTMS coil, but will not deliver a magnetic pulse. This is a no-treatment device.

Repetitive Transcranial Magnetic Stimulation to Right Dorsomedial Prefrontal Cortexdevice

Transcranial magnetic stimulation (TMS) works by delivering a magnetic pulse to a focal brain region. TMS has a high degree of safety and has been studied as an intervention for many mental health and neurological conditions. Repetitive TMS (rTMS) delivers pulses at a set time interval in order to modulate neural activity in that region.