At a glance
ClinicalIndex Comparison Record- ✓Age 25-40 years
- ✓BMI between 19 and 35 kg/m²
- ✓Low ovarian reserve defined as AMH ≤1.5 ng/mL, AFC ≤6 follicles, or ≤5 oocytes in prior cycle
- ✕History of >3 consecutive previous unsuccessful IVF cycles
- ✕PCOS diagnosis by Rotterdam criteria
- ✕BMI <19 or >35 kg/m²
- ✕Oral contraceptives used within 3 months of treatment start
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Double Trigger and Ovum Retrieval vs. Conventional Antagonist Ovarian Stimulation Protocol in Poor Prognosis Women Undergoing IVF/ICSI: A Pilot Randomized Study
In Brief
A Phase 4 clinical trial evaluating Corifollitoropin alfa (CFA)-double pick up for Fertility Disorders. Completed, enrolled 48 participants across 1 site.
Detailed Summary
The purpose of this randomized pilot study is to compare the efficacy of double oocyte retrieval vs. conventional antagonist ovarian stimulation protocol in poor prognosis patients undergoing in vitro fertilization (IVF) or intra-cytoplasmic sperm injection (ICSI).
Study Details
Timeline
Interventions
In the study group, 225 IU of recombinant FSH (rFSH) will continue after the first oocyte retrieval (OR). Antagonist administration will be initiated when at least one follicle measuring ≥14 mm will be present in the ultrasound. If one or more follicles ≥17 mm are observed, patients will undergo a second triggering with human chorionic gonadotropin (hCG) 5000 IU and a second OR will be performed. In case of patients with no follicular development following 10 additional days of rFSH post-OR