At a glance
ClinicalIndex Comparison Record- ✓Biologically female and premenopausal
- ✓Age 25-44 years
- ✓Good general health as evaluated at baseline
- ✕Current Axis I psychiatric disorder including major depressive disorder and substance dependence
- ✕Lifetime history of suicide attempt or inpatient psychiatric admission
- ✕Chronic mental or physical illness
- ✕History of allergies, autoimmune, liver, or other severe chronic diseases
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Sleep and Healthy Aging Research on Depression for Younger Women
In Brief
A Phase 1 clinical trial evaluating Endotoxin and Placebo for Anhedonia and Depression. Completed, enrolled 40 participants across 1 site.
Detailed Summary
Compelling evidence indicates inflammation plays a role in depression, but potential mechanisms linking inflammation to depression, such as dysregulated reward processing, are poorly understood. This study comprehensively evaluates effects of inflammation on reward across dimensions (e.g., anticipating versus receiving a reward) and types (e.g., money vs. smiling faces) in younger and older women. Characterizing how inflammation shapes the dynamic and multidimensional reward system, and how this may differ by age, may give insight into risk factors for depression and help identify critical points for intervention.
Study Details
Timeline
Interventions
Endotoxin
Placebo