At a glance
ClinicalIndex Comparison Record- ✓Men aged 18–39 years
- ✓Born at altitudes less than 2,100 m (~7,000 feet)
- ✓Physically active: 2–4 days per week of aerobic and/or resistance exercise
- ✓Willing to refrain from alcohol, smokeless nicotine products, and dietary supplements during study periods
- ✕Born at altitudes ≥2,100 m or lived in/traveled to areas ≥1,200 m for ≥5 days in the last 2 months
- ✕Metabolic or cardiovascular abnormalities on resting ECG
- ✕Gastrointestinal, renal, or diabetes-related disorders
- ✕Medications affecting macronutrient metabolism or ability to exercise strenuously
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The Mechanistic Effects of Acute Hypobaric Hypoxia on Exogenous Carbohydrate Utilization During Steady-state Aerobic Exercise
In Brief
A clinical study evaluating Sea Level and High Altitude for Glucose Metabolism and High Altitude. Completed, enrolled 10 participants across 1 site.
Detailed Summary
Recent studies have reported that oxidation of exogenous carbohydrate is reduced under acute hypobaric hypoxic (high altitude; HA) conditions compared to normoxia (sea level; SL) in native lowlanders. However, the mechanisms by which HA suppresses exogenous carbohydrate oxidation are not known. This study will seek to confirm that acute HA exposure decreases exogenous carbohydrate oxidation during steady-state aerobic exercise compared to SL, and explore if the mechanism inhibiting plasma glucose uptake is insulin dependent or independent.
Study Details
Timeline
Interventions
Carbohydrate consumed at 1.8 g/min during treadmill exercise at SL
Carbohydrate consumed at 1.8 g/min during treadmill exercise at HA