At a glance
ClinicalIndex Comparison Record- ✓Age 55–85 years
- ✓Positive diagnosis or strong suspicion of colon cancer (pathology-based)
- ✓Scheduled for curative resection of non-metastatic colon cancer
- ✓Reduced exercise capacity: 6-Minute Walk Test ≤80% predicted for age/sex (indicates frailty)
- ✕Any condition preventing walking or mobility
- ✕Conditions in which arm compression or transient ischemia is contraindicated (e.g., arm wounds)
- ✕Neurodegenerative disorder
- ✕Unstable angina within previous month
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Prehabilitation of Frail Surgical Cancer Patients Using Remote Ischemic Preconditioning
In Brief
A clinical study evaluating Remote Ischemic Preconditioning for Colon Cancer and 3 related conditions. Completed, enrolled 17 participants across 1 site.
Detailed Summary
This project will examine the efficacy of a simple, cost-effective, non-invasive intervention, called remote ischemic preconditioning (RIPC), to reduce frailty in pre-surgical, frail, elderly patients with colon cancer. The investigators hypothesize that RIPC will reduce frailty in the pre-surgical period (as assessed by distance walked during the 6-minute walk test), improve functional capacity 4-weeks postoperatively, and reduce intraoperative blood pressure variability. If successful, future studies will examine the efficacy of RIPC to improve surgical outcomes in frail cancer patients.
Study Details
Timeline
Interventions
Remote Ischemic Preconditioning (RIPC) occurs when a limb is made transiently ischemic (5 minutes) using a simple blood pressure cuff. We are proposing that study participants in the RIPC group perform the intervention daily at home for at least 14 days prior to scheduled surgery. They will inflate a blood pressure cuff on the upper portion of their nondominant arm, inflate it to 225 mmHg for 5 minutes, release the cuff for 5 minutes, and repeat this 5 times (for a total of 45 minutes). A study coordinator will monitor compliance with phone calls and daily log sheets that must be filled out.