At a glance
ClinicalIndex Comparison RecordPhase 4Completed· 45 enrolled
Drug / intervention
Ketamine +1 moredrug
Likely dose
Ketamine 0.5 mg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Double-blind Trial of Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery
In Brief
A Phase 4 clinical trial evaluating Ketamine and Normal saline (placebo) for Major Depressive Disorder and 2 related conditions. Completed, enrolled 45 participants across 1 site.
Detailed Summary
This study evaluates whether ketamine, given as part of an anesthetic, improves depression symptoms in depressed patients undergoing non-cardiac surgery. Half of participants will receive a ketamine infusion during surgery, while the other half will receive a placebo (normal saline) during surgery.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMajor Depressive Disorder, Surgery, Orthopedic Disorder
CountriesUnited States
Collaborators--
Timeline
Phase 4CompletedFinished
20192020202120222023202420252026
First PostedMar 2019
Enrollment StartAug 2019
Primary CompletionSep 2022
Study CompletionSep 2022
TodayJul 2026
First PostedMar 5, 2019
Enrollment StartAug 22, 2019
Primary CompletionSep 22, 2022
Study CompletionSep 27, 2022
TodayJul 2, 2026
Enrollment to primary: 3.1 yearsPosted 7.3 years ago
Interventions
Ketaminedrug
0.5 mg/kg over 40 minutes, intravenous.
Normal saline (placebo)drug
Normal saline infusion over 40 minutes, equivalent volume to ketamine infusion.