At a glance
ClinicalIndex Comparison RecordPhase 4Completed· 128 enrolled
Drug / intervention
Ephedrine +5 moredrug
Likely dose
Ephedrine 0,1 mg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
"Haemodynamic Stability During Induction of General Anesthesia With Propofol and Remifentanil: A Randomized, Controlled, Double-blind Study Comparing Equipotent Prophylactic Doses of Ephedrine, Phenylephrine, Norepinephrine vs Placebo."
In Brief
A Phase 4 clinical trial evaluating Ephedrine, Phenylephrine, and 4 other interventions for Hemodynamic Instability and 2 related conditions. Completed, enrolled 128 participants across 1 site.
Detailed Summary
In this trial the investigators want to examine if there is any difference in hemodynamic stability when giving equipotent prophylactic injections of ephedrine 0,1 mg/kg, phenylephrine 1 microg/kg, norepinephrine 0,1 microg/kg or sodium chloride (NaCl) 9 mg/ml during induction of general anesthesia with propofol and remifentanil.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesNorway
Collaborators--
Timeline
Phase 4CompletedFinished
20192020202120222023202420252026
First PostedMar 2019
Enrollment StartMar 2022
Primary CompletionDec 2023
TodayJul 2026
First PostedMar 6, 2019
Enrollment StartMar 15, 2022
Primary CompletionDec 14, 2023
TodayJul 2, 2026
Enrollment to primary: 1.7 yearsPosted 7.3 years ago
Interventions
Ephedrinedrug
0,1 mg/kg
Phenylephrinedrug
1 microg/kg
Norepinephrinedrug
0,1 microg/kg
Sodium chloridedrug
0,1 ml/kg
Propofoldrug
2 mg/kg
Remifentanildrug
1,7 microg/kg