CI

At a glance

ClinicalIndex Comparison Record
Phase 3Active· 810 enrolled
Drug / intervention
Durvalumab +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03875235
NCT03875235Phase 3Active

A Phase III Randomized, Double-Blind Placebo Controlled, Multi-Regional, International Study of Durvalumab in Combination With Gemcitabine Plus Cisplatin Versus Placebo in Combination With Gemcitabine Plus Cisplatin for Patients With First-Line Advanced Biliary Tract Cancers

AstraZeneca·interventional·Posted Mar 14, 2019·Updated May 26, 2026

In Brief

A Phase 3 clinical trial evaluating Durvalumab and Placebo for Biliary Tract Neoplasms. Active but no longer recruiting, targeting 810 participants across 126 sites in 17 countries.

Detailed Summary

Durvalumab or Placebo in Combination With Gemcitabine/Cisplatin in Patients With 1st Line Advanced Biliary Tract Cancer (TOPAZ-1).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesArgentina, Bulgaria, Chile, China, France, Hong Kong, India, Italy, Japan, Poland, Russia, South Korea, Taiwan, Thailand, Turkey (Türkiye), United Kingdom, United States
Collaborators--

Timeline

Phase 3Active
201920202021202220232024202520262027
First PostedMar 14, 2019
Enrollment StartApr 16, 2019
Primary CompletionAug 11, 2021
Study CompletionMay 16, 2027
TodayJul 2, 2026
Enrollment to primary: 2.3 yearsPosted 7.3 years ago

Interventions

Durvalumabdrug

IV infusion every 3 weeks with gemcitabine plus cisplatin up to 8 cycles followed by monotherapy every 4 weeks until disease progression or other discontinuation criteria.

Placebodrug

IV infusion every 3 weeks with gemcitabine plus cisplatin up to 8 cycles followed by monotherapy every 4 weeks until disease progression or other discontinuation criteria.