CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 599 enrolled
Drug / intervention
Cognitive Games Trainingbehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03878147
NCT03878147N/ACompleted

Culture-Specific Neurodevelopmental Assessment of HIV-affected Children

Michigan State University·interventional·Posted Mar 18, 2019·Updated Apr 20, 2025

In Brief

A clinical study evaluating Cognitive Games Training for BPG Intervention and Control. Completed, enrolled 599 participants across 2 sites in 2 countries.

Detailed Summary

The investigators will use Brain Power Games as a neurocognitive "stress test" or medical "challenge" test, in order to evaluate or improve brain/behavior functional integrity in HIV-affected children. This dual use of BPG is a key innovative feature. Each of the 5 core BPG games lasts 10 minutes and trains fine motor, monitoring/attention, visual/auditory working memory, spatial navigational learning. The investigator's central hypothesis is that the BPG performance gains will be improved compared to waitlist control for children in Uganda and Malawi.

Study Details

Timeline

N/ACompletedFinished
2020202120222023202420252026
First PostedMar 18, 2019
Enrollment StartMar 30, 2020
Primary CompletionFeb 29, 2024
Study CompletionDec 23, 2024
TodayJul 2, 2026
Enrollment to primary: 3.9 yearsPosted 7.3 years ago

Interventions

Cognitive Games Trainingbehavioral

Brain Powered Games (BPG) uses games for neurocognitive assessment and training, using images and sounds more familiar to African children. As a computerized cognitive rehabilitation training (CCRT) program designed for Sub-Saharan African school-age children, it can help children infected affected directly or indirectly by HIV. BPG consists of 5 core games evaluating different cognitive abilities (learning, memory, language, attention). Each game includes a visual tutorial, several adjustable settings on the administrative side (Admin), and records game play data for research purposes. Village Builder (VB) is a pro-social reasoning/planning world building strategy type game intended to evaluate frontal lobe executive functions in a culture-friendly and enjoyable game manner. It consists of many of the village artistic components as used in BPG but orchestrated into a village setting where children must gather resources and protect them in order to expand the capacity of the village.