CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 1,468 enrolled
Drug / intervention
Individualized high PEEP strategyprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03884543
NCT03884543N/ACompleted
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Driving Pressure During General Anesthesia for Open Abdominal Surgery (DESIGNATION) - a Randomized Clinical Trial

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)·interventional·Posted Mar 21, 2019·Updated Nov 19, 2025

In Brief

A clinical study evaluating Individualized high PEEP strategy for Postoperative Respiratory Complication. Completed, enrolled 1,468 participants across 22 sites in 3 countries.

Detailed Summary

The purpose of this international multicenter, patient and outcome-assessor blinded randomized controlled trial is to determine whether the application of an individualized high PEEP strategy, aiming at avoiding an increase in the driving pressure during intraoperative ventilation, protects against the development of postoperative pulmonary complications.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPostoperative Respiratory Complication
CountriesGermany, Italy, Netherlands
CollaboratorsAmsterdam UMC, location VUmc, Noord West Ziekenhuizen location Alkmaar, University Medical Center Groningen, Radboud University Medical Center, HagaZiekenhuis, Rijnstate Hospital, Medical Center Haaglanden, Bernhoven Hospital, Onze Lieve Vrouwe Gasthuis, Albert Schweitzer Hospital, Frisius Medisch Centrum, Leiden University Medical Center, Maastricht University Medical Center, Martini Hospital Groningen, Erasmus Medical Center, Spaarne Gasthuis, University Hospital Carl Gustav Carus, Bermanntrost BG Klinikum Halle, Heinrich-Heine University, Duesseldorf, Ospedale Policlinico San Martino, Jeroen Bosch Ziekenhuis, Meander Medical Center, Isala, Alrijne Hospital, Antoni van Leeuwenhoek Ziekenhuis, Medisch Spectrum Twente, Campus Bio-Medico University, Istituto Nazionale Tumori IRCCS - Fondazione G. Pascale, University of Roma La Sapienza, University of Campania Luigi Vanvitelli, Hospital Universitario La Fe, Medical University Innsbruck

Timeline

N/ACompletedFinished
2020202120222023202420252026
First PostedMar 21, 2019
Enrollment StartApr 23, 2019
Primary CompletionMar 11, 2025
Study CompletionJun 1, 2025
TodayJul 2, 2026
Enrollment to primary: 5.9 yearsPosted 7.3 years ago

Interventions

Individualized high PEEP strategyprocedure

Patients are randomized and intra-operatively ventilated with an individualized high PEEP strategy (Highest PEEP with the lowest driving pressure with recruitment maneuvers)