CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 305 enrolled
Drug / intervention
SDP-4 Ophthalmic Solution (0.1%) +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03889886
NCT03889886Phase 2Completed

A Phase 2, Multicenter, Double-Masked, Randomized, Vehicle-Controlled, Parallel Group, Dose-Response Study of SDP-4 Ophthalmic Solution in Subjects With Dry Eye Disease (DED)

Silk Technologies, Ltd.·interventional·Posted Mar 26, 2019·Updated Sep 2, 2022

In Brief

A Phase 2 clinical trial evaluating SDP-4 Ophthalmic Solution (0.1%), SDP-4 Ophthalmic Solution (1.0%), and 2 other interventions for Dry Eye. Completed, enrolled 305 participants across 26 sites.

Detailed Summary

SDP-4-CS201, is a Phase 2, multi-center, double-masked, randomized, vehicle-controlled, dose-response, parallel-group study designed to evaluate the ocular and systemic safety and efficacy of SDP-4 ophthalmic solution in subjects with moderate to severe dry eye disease over a 12-week treatment period. Three concentrations (0.1%, 1.0% and 3.0%) of SDP-4 ophthalmic solution will be given to parallel groups via topical ocular instillation BID.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDry Eye
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
2020202120222023202420252026
First PostedMar 26, 2019
Enrollment StartApr 16, 2019
Primary CompletionOct 7, 2019
Study CompletionOct 11, 2019
TodayJul 2, 2026
Enrollment to primary: 6 monthsPosted 7.3 years ago

Interventions

SDP-4 Ophthalmic Solution (0.1%)drug

Investigational product (IP) will be administered via topical ocular instillation, one drop per eye, twice daily (BID) for 12 weeks (84 days). Both eyes will be treated.

SDP-4 Ophthalmic Solution (1.0%)drug

Investigational product (IP) will be administered via topical ocular instillation, one drop per eye, twice daily (BID) for 12 weeks (84 days). Both eyes will be treated.

SDP-4 Ophthalmic Solution (3.0%)drug

Investigational product (IP) will be administered via topical ocular instillation, one drop per eye, twice daily (BID) for 12 weeks (84 days). Both eyes will be treated.

Vehicledrug

Investigational product (IP) will be administered via topical ocular instillation, one drop per eye, twice daily (BID) for 12 weeks (84 days). Both eyes will be treated.