CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 47 enrolled
Drug / intervention
Active tDCS + task oriented practice +1 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03892746
NCT03892746Phase 2Completed
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Improving SCI Rehabilitation Interventions by Retraining the Brain

The Cleveland Clinic·interventional·Posted Mar 27, 2019·Updated Dec 10, 2025

In Brief

A Phase 2 clinical trial evaluating Active tDCS + task oriented practice and Sham tDCS + task oriented practice for Cervical Spinal Cord Injruy. Completed, enrolled 47 participants across 4 sites.

Detailed Summary

The Long-term goal of this project is to develop upper limb rehabilitation interventions that can be utilized for cervical Spinal Cord Injury survivors. This Study will utilize a novel method of non-invasive brain stimulation in conjunction with upper limb training given for 15 sessions over several weeks up to 8 weeks. The Study will include the following site visits: * Eligibility Screening and Informed Consent Visit. * Four testing visit in which motor function of the upper limb and neurophysiology will be measured * Fifteen intervention visits during which patients will receive upper limb training in conjunction with non-invasive brain stimulation * Repeat testing of motor function and neurophysiology of the upper limb following completion of intervention visits * a Follow-up visit completed 3 months after the completion of interventions

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCervical Spinal Cord Injruy
CountriesUnited States
CollaboratorsCongressionally Directed Medical Research Programs, United States Department of Defense

Timeline

Phase 2CompletedFinished
2020202120222023202420252026
First PostedMar 27, 2019
Enrollment StartJul 12, 2019
Primary CompletionSep 29, 2024
Study CompletionOct 9, 2024
TodayJul 2, 2026
Enrollment to primary: 5.2 yearsPosted 7.3 years ago

Interventions

Active tDCS + task oriented practicedevice

Participants in this arm will receive active tDCS (2mA) to the motor cortex (targeting the triceps) of the weaker upper limb for 2, 30-minute cycles during each 2-hour upper limb training session. While receiving tDCS, the participant will be performing task-oriented practice for the weaker upper limb. Participants will receive these interventions for 15 sessions over several weeks up to 8 weeks.

Sham tDCS + task oriented practicedevice

Participants in this arm will receive sham tDCS (0mA) to the motor cortex (targeting the triceps) of the weaker upper limb for 2, 30-minute cycles during each 2-hour upper limb training session. While receiving tDCS, the participant will be performing task-oriented practice for the weaker upper limb. Participants will receive these interventions for 15 sessions over several weeks up to 8 weeks.