CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 86 enrolled
Drug / intervention
Ibuprofen +3 moredrug
Likely dose
Ibuprofen 400 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03893175
NCT03893175Phase 1Completed
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Towards Predicting the Analgesic Response to Ibuprofen Following Third-molar Extraction

University of Pennsylvania·interventional·Posted Mar 28, 2019·Updated Jul 24, 2025

In Brief

A Phase 1 clinical trial evaluating Ibuprofen, Acetaminophen, and 2 other interventions for Impacted Third Molar Tooth and Pain, Acute. Completed, enrolled 86 participants across 1 site.

Detailed Summary

This research study will evaluate inter-individual variability in the analgesic response to the non-steroidal anti-inflammatory drug (NSAID) ibuprofen after third molar extraction surgery. It will also investigate demographic, clinical, genetic, and environmental factors that cause this variability.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsImpacted Third Molar Tooth, Pain, Acute
CountriesUnited States
Collaborators--

Timeline

Phase 1CompletedFinished
2020202120222023202420252026
First PostedMar 28, 2019
Enrollment StartMay 10, 2019
Primary CompletionMar 2, 2022
TodayJul 2, 2026
Enrollment to primary: 2.8 yearsPosted 7.3 years ago

Interventions

Ibuprofendrug

400 mg by mouth every 4 hours for 2 days after third molar extraction and then as needed for pain up to 7 days after third molar extraction

Acetaminophendrug

500 mg by mouth every 4 hours for 2 days after third molar extraction and then as needed for pain up to 7 days after third molar extraction

Placebodrug

By mouth

Oxycodonedrug

5 mg by mouth every 6 hours as needed for pain