At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Comparison of Nebulized Sub-dissociative Dose Ketamine at Three Different Dosing Regimens for Treating Acute and Chronic Painful Conditions in the ED: A Prospective, Randomized Trial
In Brief
A Phase 4 clinical trial evaluating Ketamine 0.75 mg/kg, Ketamine 1.0 mg/kg, and 1 other intervention for Pain. Completed, enrolled 120 participants across 1 site.
Detailed Summary
The investigators previous research study comparing the efficacy of intravenous ketamine to morphine showed ketamine to provide equivalent relief of moderate to severe acute pain in emergency department patients. A second study by the investigators showed that increasing the time of administration of the ketamine, from a push injection to a drip infusion, will minimize the adverse effects experienced by recipients of ketamine. The investigators now aim to see if nebulized subdissociative-dose ketamine administered as a single agent in a dose of 1.5 mg/kg via Breath-Actuated Nebulizers (BAN) over 5-15 minutes will provide a better pain relief in comparison to 1 mg/kg and 0.75 mg/kg doses or if the lower doses are equally as effective.
Study Details
Timeline
Interventions
Patients with moderate to severe pain will receive Ketamine at a dose of 0.75mg/kg
Patients with moderate to severe pain will receive Ketamine at a dose of 1.0 mg/kg
Patients with moderate to severe pain will receive Ketamine at a dose of 1.5 mg/kg