CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 416 enrolled / 416 target
Drug / intervention
MACRO-I +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03922529
NCT03922529N/ACompletedHigh Momentum (5.2/mo)Completion was 22mo ago
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Modified Application of Cardiac Rehabilitation for Older Adults

Daniel Forman, MD·interventional·Posted Apr 22, 2019·Updated Jun 29, 2026

In Brief

A clinical study evaluating MACRO-I and Usual Care for Cardiovascular Diseases and 2 related conditions. Completed, enrolled 416 participants across 3 sites.

Signals

Enrolling ahead of pace

Detailed Summary

Modified Application of Cardiac Rehabilitation for Older Adults (MACRO) responds to a critical underuse of cardiac rehabilitation in older adults with a coaching model that addresses issues related to aging as a means to better facilitate cardiac rehabilitation (CR). MACRO is a randomized controlled trial (RCT) in which older adults with a CVD event are randomized between a MACRO intervention (MACRO-I) versus usual care. The MACRO-I is designed to facilitate CR as a means to augment functional recovery.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCardiovascular Diseases, Cardiac Rehabilitation, Transition of Care
CountriesUnited States
CollaboratorsNational Institute on Aging (NIA), Washington University School of Medicine, University of Pittsburgh

Timeline

N/ACompletedFinished
2020202120222023202420252026
First PostedApr 22, 2019
Enrollment StartNov 4, 2019
Primary CompletionAug 8, 2024
TodayJul 2, 2026
Enrollment to primary: 4.8 yearsPosted 7.2 years ago

Arms & Interventions

Usual Careactive_comparator

Care after an acute heart event will be at the discretion of the participants' clinical providers.

Other: Usual Care
MACRO-Iexperimental

A coaching intervention that supplements usual care.

Behavioral: MACRO-I

Interventions

MACRO-Ibehavioral

MACRO-I coaches engage with patients regularly while they are still inpatients, and then by telephone once they are discharged. Coaching incorporates innovative techniques for holistic risk assessment (medical, functional, psychosocial), guidance to initiate CR in a format aligned with each patient's risks and preferences (i.e., CR as either site-based, home-based, or in a hybrid format \[site transitioning to home\]), behavioral prompts based on their personal goals of care, and de-prescribing of sedating medications.

Usual Careother

Participants will receive usual care that is recommended by their providers. MACRO study personnel will follow the participant for the course of the study to assess endpoints in comparison to the MACRO-I arm.