CI

At a glance

ClinicalIndex Comparison Record
Early Ph 1Completed· 66 enrolled
Drug / intervention
Marinol 10Mg Capsule TMS Sham +5 moredrug
Likely dose
Marinol 10Mg Capsule TMS Shamfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03944954
NCT03944954Early Ph 1Completed
CompareCT.gov

Neural Mechanisms of Cannabinoid-impaired Decision-Making in Emerging Adults

Michael J. Wesley, PhD·interventional·Posted May 10, 2019·Updated Apr 5, 2024

In Brief

A Early Phase 1 clinical trial evaluating Placebo TMS Sham, Marinol 10Mg Capsule TMS Sham, and 4 other interventions for Neurosciences and 2 related conditions. Completed, enrolled 66 participants across 1 site.

Detailed Summary

Emerging adults are a particularly vulnerable group for experiencing the immediate and potentially lifelong negative impacts of habitual cannabis use, and trends suggest that cannabis use disorder (CUD) will soon escalate in this population. The proposed research will combine clinical pharmacology, non-invasive brain stimulation, and neuroimaging techniques to establish the brain mechanisms of cannabinoid-impaired decision-making processes in emerging adults with CUD. Results from this project will inform CUD prevention/treatment efforts in this high-risk group and address a growing public health concern.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsNeurosciences, Substance-Related Disorders, Behavior Problem
CountriesUnited States
CollaboratorsNational Institute on Drug Abuse (NIDA)

Timeline

Early Ph 1CompletedFinished
201820192020202120222023202420252026
First PostedMay 10, 2019
Enrollment StartJul 15, 2017
Primary CompletionDec 13, 2023
TodayJul 2, 2026
Enrollment to primary: 6.4 yearsPosted 7.1 years ago

Interventions

Placebo TMS Shamdevice

Individuals will receive placebo dose and sham TMS.

Marinol 10Mg Capsule TMS Shamdrug

Individuals will receive 10mg dose and sham TMS.

Marinol 30Mg Capsule TMS Shamdrug

Individuals will receive 30mg dose and sham TMS.

Placebo TMS Realdevice

Individuals will receive placebo and real TMS.

Marinol 10Mg Capsule TMS Realother

Individuals will receive10mg THC and real TMS. Intervention type: Other (combination device/drug intervention)

Marinol 30Mg Capsule TMS Realother

Individuals will receive 30mg THC and real TMS. Intervention type: Other (combination device/drug intervention)