At a glance
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The Effect of Alpha-tocopherol in Hemolysis and Oxidative Stress Marker on the Red Cell
In Brief
A clinical study evaluating Alpha-Tocopherol and Placebo oral tablet for Beta Thalassemia Major Anemia and 2 related conditions. Completed, enrolled 40 participants across 1 site.
Detailed Summary
The accumulation of unpaired α-globin chains in β-thalassemia major patients may clinically create ineffective erythropoiesis, hemolysis, and chronic anemia. Multiple blood transfusions and iron overload cause cellular oxidative damage. However, α-tocopherol, an antioxidant, has been known as a potent scavenger of lipid radicals in the red cell membrane of β-thalassemia major patient. By this randomized controlled trial, the investigators would like to evaluate the effects of α-tocopherol in hemolysis and oxidative stress on the red cell membrane of β-thalassemia major.
Study Details
Timeline
Interventions
all of the subjects in the alpha-tocopherol group received alpha-tocopherol orally, doses adjusted by age for 4 weeks of treatment.