CI

At a glance

ClinicalIndex Comparison Record
N/AActive· 4 enrolled
Drug / intervention
Deep Brain Simulatordevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03950492
NCT03950492N/AActive
CompareCT.gov

Feasibility of Deep Brain Stimulation as a Novel Treatment for Refractory

West Virginia University·interventional·Posted May 15, 2019·Updated Jul 28, 2025

In Brief

A clinical study evaluating Deep Brain Simulator for Opioid-Related Disorders. Active but no longer recruiting, targeting 4 participants across 1 site.

Detailed Summary

The purpose of this clinical study is to investigate the safety, tolerability, and feasibility of Deep Brain Stimulation (DBS) of the nucleus accumbens (NAc) and ventral internal capsule (VC) for participants with treatment refractory opioid use disorder (OUD) who have cognitive, behavioral, and functional disability. This study will also provide critical information for planning subsequent clinical trials.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsOpioid-Related Disorders
CountriesUnited States
CollaboratorsNational Institute on Drug Abuse (NIDA), Medtronic

Timeline

N/AActive
20202021202220232024202520262027
First PostedMay 15, 2019
Enrollment StartSep 30, 2019
Primary CompletionDec 31, 2022
Study CompletionDec 31, 2026
TodayJul 2, 2026
Enrollment to primary: 3.3 yearsPosted 7.1 years ago

Interventions

Deep Brain Simulatordevice

This is an open-label, safety, tolerability, and feasibility study for participants who have treatment refractory OUD that are eligible to have DBS targeting the NAc/VC.