CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 287 enrolled / 287 target
Drug / intervention
Ibuprofen 600 mg +3 moredrug
Likely dose
Ibuprofen 600 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03978767
NCT03978767Phase 2CompletedHigh Momentum (3.4/mo)
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Preeclampsia And Nonsteroidal Drugs for Analgesia (PANDA): a Randomized Non Inferiority Trial

Washington University School of Medicine·interventional·Posted Jun 7, 2019·Updated Jun 22, 2026

In Brief

A Phase 2 clinical trial evaluating Ibuprofen 600 mg, Ketorolac, and 2 other interventions for Preeclampsia Severe and Preeclampsia Postpartum. Completed, enrolled 287 participants across 1 site.

Signals

Enrolling ahead of pace

Detailed Summary

A randomized non-inferiority trial of women with preeclampsia with severe features to determine if the addition of nonsteroidal anti-inflammatory drugs is inferior or non-inferior to standard analgesic bundles in their impact on postpartum hypertension.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPreeclampsia Severe, Preeclampsia Postpartum
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
2020202120222023202420252026
First PostedJun 7, 2019
Enrollment StartJun 10, 2019
Primary CompletionJun 15, 2026
TodayJul 2, 2026
Enrollment to primary: 7.0 yearsPosted 7.1 years ago

Arms & Interventions

NSAID Analgesic bundleexperimental

Ibuprofen 600mg PO q 6 hrs as needed for pain, Acetaminophen 1000mg q 8 hrs as needed for pain, and Oxycodone 5 to 10 mg q 4 hrs as needed for pain. In patients undergoing cesarean section, ketorolac 30mg IV q 6 hrs may be substituted as an IV alternative to ibuprofen for the first 24 hours after surgery

Drug: Ibuprofen 600 mgDrug: KetorolacDrug: AcetaminophenDrug: Oxycodone
NSAID free analgesic bundleactive_comparator

Acetaminophen 1000mg q 8 hrs as needed for pain, and Oxycodone 5 to 10 mg q 4 hrs as needed for pain.

Drug: AcetaminophenDrug: Oxycodone

Interventions

Ibuprofen 600 mgdrug

NSAID pain medication to be used in the experimental bundle for postpartum analgesia

Ketorolacdrug

NSAID analgesic to be used in the experimental bundle for postpartum analgesia in patients who underwent cesarean section

Acetaminophendrug

Analgesic medication to be used in both treatment arms

Oxycodonedrug

Analgesic medication to be used in both treatment arms