CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 707 enrolled
Drug / intervention
Driving-pressure-guided group +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03987789
NCT03987789N/ACompleted
CompareCT.gov

Intraoperative Protective Mechanical Ventilation in Patients Requiring Emergency Abdominal Surgery: IMPROVE-2 Multicenter Prospective Randomized Trial

University Hospital, Clermont-Ferrand·interventional·Posted Jun 17, 2019·Updated Apr 21, 2026

In Brief

A clinical study evaluating Driving-pressure-guided group and Low PEEP for Emergency Abdominal Surgery and 3 related conditions. Completed, enrolled 707 participants across 28 sites.

Detailed Summary

The aim of this study is to compare the effects of a strategy aimed at increasing alveolar recruitment (high PEEP levels adjusted according to driving pressure and recruitment maneuvers) with that of a strategy aimed at minimizing alveolar distension (low PEEP level without recruitment maneuver) on postoperative respiratory failure and mortality in patients receiving low VT ventilation during emergency abdominal surgery.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsEmergency Abdominal Surgery, Mechanical Ventilation, General Anesthesia, Postoperative Morbidity
CountriesFrance
Collaborators--

Timeline

N/ACompletedFinished
2020202120222023202420252026
First PostedJun 17, 2019
Enrollment StartFeb 18, 2021
Primary CompletionJul 29, 2022
Study CompletionOct 27, 2022
TodayJul 2, 2026
Enrollment to primary: 1.4 yearsPosted 7.0 years ago

Interventions

Driving-pressure-guided groupother

Patients will receive PEEP levels individually set at the highest possible value (up to 15 cmH2O) providing a driving pressure (airway plateau pressure minus PEEP) lower than 13 cmH2O, in addition to recruitment maneuvers.

Low PEEPother

Patients will receive a PEEP level ≤5 cmH2O without recruitment maneuvers