CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 52 enrolled
Drug / intervention
AXER-204 +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03989440
NCT03989440Phase 2Completed

A Multicenter, Two Part Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of AXER-204 in Subjects With Chronic Spinal Cord Injury

ReNetX Bio, Inc.·interventional·Posted Jun 18, 2019·Updated Aug 22, 2023

In Brief

A Phase 2 clinical trial evaluating AXER-204 and Placebo for Chronic Spinal Cord Injury. Completed, enrolled 52 participants across 6 sites.

Detailed Summary

This two-part trial will assess the safety, tolerability, pharmacokinetics, and efficacy of AXER-204 administered by lumbar puncture and slow bolus infusion. Part 1 will evaluate the safety, tolerability, and pharmacokinetics of single ascending doses of AXER-204. Part 2 will evaluate the safety, tolerability, pharmacokinetics, and efficacy of repeated doses AXER-204 in comparison to placebo.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
2020202120222023202420252026
First PostedJun 18, 2019
Enrollment StartJul 16, 2019
Primary CompletionJun 21, 2022
TodayJul 2, 2026
Enrollment to primary: 2.9 yearsPosted 7.0 years ago

Interventions

AXER-204drug

human NoGo Trap fusion protein

Placebodrug

Phosphate buffered saline formulation