At a glance
ClinicalIndex Comparison Record- ✓Histologically confirmed, resected oral cavity squamous cell carcinoma with at least ipsilateral selective neck dissection
- ✓Pathological features indicating need for postoperative radiotherapy: positive or close margin, LVI or PNU, pT3/pT4 disease, positive lymph nodes
- ✓Pathologically lymph node negative in at least one dissected hemi-neck with at least 10 nodes recovered
- ✕Prior head and neck radiation at any time
- ✕Prior oncologic head and neck surgery in the oral cavity or neck
- ✕Prior history of head and neck cancer within 5 years
- ✕Any other active invasive malignancy except non-melanotic skin cancers
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Preservation of Swallowing in Resected Oral Cavity Squamous Cell Carcinoma: Examining Radiation Volume Effects: A Randomized Trial
In Brief
A Phase 2 clinical trial evaluating Radiotherapy to all dissected areas and Omit radiation to pN0 neck for Head and Neck Cancer. Currently recruiting, targeting 90 participants across 8 sites in 4 countries.
Signals
Detailed Summary
The goal of this randomized treatment study is to formally compare quality of life in patients with at least one pN0 hemi-neck after resection of a squamous cell carcinoma of the oral cavity treated with a primary radiation therapy versus a secondary targeted radiation therapy approach, to provide a high level of evidence to guide the selection of treatment options.
Study Details
Timeline
Interventions
Post operative radiation therapy +/- chemotherapy based on historic treatment volumes (including the primary site, dissected areas +/- elective areas
post operation radiation therapy +/- chemotherapy that avoids targeting the dissected pN0 neck