CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 17 enrolled
Drug / intervention
Acetaminophen +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03997851
NCT03997851Phase 2Completed
CompareCT.gov

Topical Acetaminophen for Itch Relief: a Proof of Concept Study in Healthy Subjects

University of Miami·interventional·Posted Jun 25, 2019·Updated Dec 8, 2025

In Brief

A Phase 2 clinical trial evaluating Acetaminophen and Carbomer 980 for Pruritus. Completed, enrolled 17 participants across 1 site.

Detailed Summary

Currently, topical antihistamines and corticosteroids are mainly used for itching relief. However, the over the counter antihistamines are not effective on all itch conditions. Acetaminophen is a popular and widely used OTC drug for pain relief. Although its mode of action is still unknown, recent studies have shown that acetaminophen indirectly activates cannabinoid CB1 receptors. Recent studies have shown that topical cannabinoid agonists are effective for itch relief, the efficacy of topical acetaminophen will be tested for non-histaminergic itch relief.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPruritus
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
2020202120222023202420252026
First PostedJun 25, 2019
Enrollment StartJul 22, 2019
Primary CompletionMar 18, 2020
TodayJul 2, 2026
Enrollment to primary: 8 monthsPosted 7.0 years ago

Interventions

Acetaminophendrug

Topical acetaminophen gel

Carbomer 980drug

Topical vehicle gel