CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 61 enrolled
Drug / intervention
Citric acid +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03999203
NCT03999203N/ACompleted
CompareCT.gov

A Cross-sectional Study to Measure Cough in Severe Asthma

Queen's University, Belfast·interventional·Posted Jun 26, 2019·Updated Nov 22, 2023

In Brief

A clinical study evaluating Citric acid, Leicester Cough monitor, and 2 other interventions for Asthma and Cough. Completed, enrolled 61 participants across 1 site.

Detailed Summary

This study aims to characterise cough in severe asthma through an observational cross-sectional analysis of patients stratified by inflammatory biomarker profile using a number of subjective and objective cough measurement tools.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAsthma, Cough
CountriesUnited Kingdom
CollaboratorsKing's College London

Timeline

N/ACompletedFinished
201820192020202120222023202420252026
First PostedJun 26, 2019
Enrollment StartOct 4, 2017
Primary CompletionDec 30, 2019
TodayJul 2, 2026
Enrollment to primary: 2.2 yearsPosted 7.0 years ago

Interventions

Citric aciddrug

Citric Acid cough challenge to be administered to assess the cough reflex sensitivity in patients

Leicester Cough monitordevice

Ambulatory cough monitor to assess cough frequency over a 24 hour period

fractional exhaled nitric oxide testing (FeNO)other

Measurement of exhaled nitric oxide to give an indication of airway inflammation

Patient reported outcome measuresother

A number a patient reported outcome measures will be administered including: Asthma control questionnaire (ACQ-5), mini Asthma Quality of Life Questionnaire (mini AQLQ), Leicester Cough Questionnaire (LCQ), Cough Quality of Life Questionnaire (CQLQ), Cough Hypersensitivity Questionnaire (CHQ) and visual analogue scales for severity og cough (VASc) and Urge to Cough (VASu)