CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 71 enrolled
Drug / intervention
C Type Natriüretic Peptideother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04000815
NCT04000815N/ACompleted
CompareCT.gov

Serum Levels of C Type Natriuretic Peptide in Reproductive Age, Perimenopausal and Postmenopausal Women

Near East University, Turkey·interventional·Posted Jun 27, 2019·Updated Mar 11, 2020

In Brief

A clinical study evaluating C Type Natriüretic Peptide for Serum CNP Levels and 3 related conditions. Completed, enrolled 71 participants across 1 site.

Detailed Summary

Recent studies have shown that C natriuretic peptide (CNP) is produced from granulosa cells, increasing cumulative guanosine monophosphate (cGMP) production by affecting cumulus cells through natriuretic peptide receptors.It has been suggested that the transport of cGMP to oocyte via gap junctions causes a continuous increase in cyclic adenosine monophosphate (cAMP) levels within the oocyte. An important role of increased cAMP levels in oocyte is shown to suppress meiotic progression. Deoxyribonucleic acid (DNA) studies in animals have shown that expression of the natriuretic peptide precursor increases during the periovulatory period and shows that this increase decreases rapidly after Luteinizing hormone(LH) / human chorionic(hCG) stimulation. Human studies have shown that after ovulation induction, the CNP level in follicular fluid decreases following ovulatory dose of hCG (9).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsSerum CNP Levels, Healthy Reproductive Age Women, Healthy Perimenopausal Women, Healthy Postmenopausal Women
CountriesCyprus
Collaborators--

Timeline

N/ACompletedFinished
2020202120222023202420252026
First PostedJun 27, 2019
Enrollment StartJul 24, 2019
Primary CompletionJan 9, 2020
Study CompletionJan 20, 2020
TodayJul 2, 2026
Enrollment to primary: 6 monthsPosted 7.0 years ago

Interventions

C Type Natriüretic Peptideother

C Type Natriuretic Peptide will be measured with elisa method