At a glance
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Prospective Validation Trial of Taxane Therapy (Docetaxel or Weekly Paclitaxel) and Risk of Chemotherapy-Induced Peripheral Neuropathy in African American Women
In Brief
A Phase 2 clinical trial evaluating Docetaxel, Paclitaxel, and 2 other interventions for Anatomic Stage I Breast Cancer AJCC v8 and 20 related conditions. Active but no longer recruiting, targeting 249 participants across 485 sites.
Detailed Summary
This phase II trial studies whether a prior germline predictor of taxane-induced peripheral neuropathy (TIPN) can help identify a subgroup of patients who are at higher risk of chemotherapy-induced peripheral neuropathy in African American patients with stages I-III breast cancer. The study also investigates whether docetaxel maybe work better than paclitaxel with regard to TIPN rate/severity and dose reductions.
Study Details
Timeline
Interventions
Given IV
Given IV
Ancillary studies
Ancillary studies