CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 13 enrolled
Drug / intervention
blood samples collectionother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04002570
NCT04002570N/ACompleted
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Effects of Adjuvant Radiotherapy on Bone-marrow Derived and Immune Cells in Breast Cancer Patients

Clinica Luganese Moncucco·observational·Posted Jun 28, 2019·Updated Apr 27, 2021

In Brief

An observational study evaluating blood samples collection for Breast Cancer. Completed, enrolled 13 participants across 1 site.

Detailed Summary

Radiation applied to the preserved breast during radiotherapy treatment activates numerous molecular cascades in tumor bed adjacent cells causing an inflammatory state. During this process, pre-clinical studies demonstrated CD11b + and CD11b+cKit+cells mobilization in the blood. These cells are involved in numerous processes during tumor progression/control and metastases development. The expected results in clinical setting allow us to investigate the development of innovative therapeutic and monitoring strategies. The clinical repercussions would consist in identifying new predictive and prognostic targets in breast cancer.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsBreast Cancer
CountriesSwitzerland
CollaboratorsCurzio Rüegg, MD, Head of Department, University of Fribourg, Swiss National Science Foundation, Tsoutsou Pelagia MD, Head of Radation Therapy Department

Timeline

N/ACompletedFinished
20162017201820192020202120222023202420252026
First PostedJun 28, 2019
Enrollment StartOct 25, 2015
Primary CompletionSep 15, 2020
Study CompletionDec 30, 2020
TodayJul 2, 2026
Enrollment to primary: 4.9 yearsPosted 7.0 years ago

Interventions

blood samples collectionother

blood samples collection are performed at 4 different timepoints: preop, pre rt, week 6 rt, week 12-14 (fu) for GROUP I and GROUP II; blood samples collection are performed at 3 different timepoints: pre rt, week 6 rt, week 12-14 (fu) for GROUP I bis; blood samples collection are performed just once for control GROUP.