At a glance
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Long-term Morphological and Functional Retinal Changes After Topical Citicoline Administration in Patients With Mild Signs of Diabetic Retinopathy in Type 1 Diabetes Mellitus: Pilot Study
In Brief
A clinical study evaluating OMK2 group and Placebo group for Diabetic Retinopathy. Completed, enrolled 20 participants across 1 site.
Detailed Summary
Citicoline (cytidine-5'-diphosphocholine) is an essential precursor in the synthesis of phosphatidylcholine, a component of cell membranes. Several experimental in vitro and in vivo studies have suggested that citicoline plays a neuroprotective role. A recent clinical study has shown that treatment with topical citicoline induces, after 60 days of therapy, a significant improvement in the ganglion cell function .In addition topical citicoline has been demonstrated in vivo a neuroprotective effect in preventing diabetic retinopathy . The Investigators want to evaluate if citicoline may reduce the progression of retinal damage in patients with mild diabetic retinopathy.
Study Details
Timeline
Interventions
topical administration of OMk2 ophthalmic solution for 36 months three times/day
topical administration of ophthalmic placebo solution for 36 months three times/day