CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 31 enrolled
Drug / intervention
GMK Sphere TKRprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04017533
NCT04017533N/ACompleted

In Vivo Stability of an Uncemented Total Knee Arthroplasty With Medially Stabilized Design

Oslo University Hospital·interventional·Posted Jul 12, 2019·Updated Nov 25, 2025

In Brief

A clinical study evaluating GMK Sphere TKR for Knee Osteoarthritis. Completed, enrolled 31 participants across 1 site.

Detailed Summary

Total joint replacement is an efficacious treatment for osteoarthritis of hips and knees. Both total knee replacement (TKR) and total hip replacements (THR) have excellent implant survivorship. However, patients' satisfaction is lower in TKR than THR. A possible cause of the discrepancy is the unnatural knee kinematics after TKR. Various implants designs have been developed to solve the problem. The most common fixation mode is cemented TKR with good survival up to 15 years. However, newer series in younger patients also have shown lasting survival with uncemented implants (Nilsson et al 2006, Prudhon et al. 2017). Among various different designs, medially stabilized total knee, which are designed to reproduce natural knee kinematics with medial ball-in-socked design, is a promising implant (Australian registry report 2018). Dynamically the medial pivot knee performs more naturally (Bragnazoli et al, 2019) compared to other designs. Most data for this design is available only for the cemented version. Up to now there is no safety study performed that confirms the stability over time for this implant with uncemented fixation. In this study, we will therefore analyze the in vivo stability of an uncemented knee implant with medially stabilized design. Our study will contribute to the understanding of fixation and lead to safety to the patient.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesNorway

Timeline

N/ACompletedFinished
2020202120222023202420252026
First PostedJul 12, 2019
Enrollment StartSep 4, 2021
Primary CompletionOct 10, 2024
TodayJul 2, 2026
Enrollment to primary: 3.1 yearsPosted 7.0 years ago

Interventions

GMK Sphere TKRprocedure

Se earlier