CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 360 enrolled
Drug / intervention
WhatsApp Group +3 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04038060
NCT04038060N/ACompleted
CompareCT.gov

Evaluation of Stepped PrEP (Pre-exposure Prophylaxis) Adherence Support for Young South African Women Using a SMART Design

University of Washington·interventional·Posted Jul 30, 2019·Updated May 4, 2026

In Brief

A clinical study evaluating WhatsApp Group, 2-way SMS, and 2 other interventions for HIV/AIDS. Completed, enrolled 360 participants across 1 site.

Detailed Summary

The PrEP SMART study is testing a stepped model of scalable adherence support strategies in South African young women who initiate PrEP using a SMART (sequential multiple assignment randomized trial) design.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHIV/AIDS
CountriesSouth Africa
CollaboratorsWits Reproductive Health and HIV Institute, National Institute of Mental Health (NIMH)

Timeline

N/ACompletedFinished
2020202120222023202420252026
First PostedJul 30, 2019
Enrollment StartMay 16, 2019
Primary CompletionOct 27, 2021
Study CompletionJan 25, 2022
TodayJul 2, 2026
Enrollment to primary: 2.4 yearsPosted 6.9 years ago

Interventions

WhatsApp Groupbehavioral

Participants will receive peer adherence support through WhatsApp groups

2-way SMSbehavioral

Participants will receive healthcare worker adherence support through 2-way SMS

Drug level feedbackbehavioral

Participants will receive adherence counseling based on tenofovir drug levels

Monthly counseling sessionsbehavioral

Participants will receive monthly counseling on a variety of issues that may be impacting their PrEP adherence