CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 2,905,455 enrolled
Drug / intervention
Routine cluster detection +1 moreother
Likely dose
Not stated in record
Key inclusion· 2
  • ✓All U.S. HCA Healthcare hospitals that provide inpatient care
  • ✓Facilities that are reporting to the centralized data warehouse during the study period
Key exclusion· 0

None specified.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04053075
NCT04053075N/ACompleted
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Cluster Linkage Using Statistics to Trigger and Evaluate Response (CLUSTER) Trial for Outbreak Detection and Response

Harvard Pilgrim Health Care·interventional·Posted Aug 12, 2019·Updated Jan 16, 2025

In Brief

A clinical study evaluating Routine cluster detection and Enhanced cluster detection for Cluster Detection. Completed, enrolled 2,905,455 participants across 82 sites.

Detailed Summary

Despite the critical importance of identifying hospital-associated outbreaks as early as possible in order to limit their spread, there are currently no standardized methods for cluster detection. The CLUSTER Trial (Cluster Linkage Using Statistics to Trigger and Evaluate Response) will assess whether a statistically-based automated cluster detection method coupled with a robust response protocol will enable rapid containment of hospital clusters as measured by a reduction in cluster size and duration as compared to routine hospital cluster detection methods coupled with the same response protocol. Note: that enrolled "subjects" represents 82 individual HCA Healthcare hospitals that have been randomized

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCluster Detection
CountriesUnited States
CollaboratorsHospital Corporation of America, Brigham and Women's Hospital, University of California, Irvine, Harvard School of Public Health (HSPH), Rush University, Duke University, University of Massachusetts, Amherst, University of California, San Francisco, Cook County Health & Hospitals System, Centers for Disease Control and Prevention

Timeline

N/ACompletedFinished
2020202120222023202420252026
First PostedAug 12, 2019
Enrollment StartJul 23, 2019
Primary CompletionMay 20, 2024
TodayJul 2, 2026
Enrollment to primary: 4.8 yearsPosted 6.9 years ago

Interventions

Routine cluster detectionother

Hospitals will use routine practices for cluster detection with a structured cluster response protocol when a cluster is detected.

Enhanced cluster detectionother

Hospitals will use an automated statistical cluster detection tool in addition to routine practices for cluster detection with a structured cluster response protocol when a cluster is detected.