At a glance
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Analgesic Efficacy of Naproxen-codeine, Naproxen+Dexamethasone, and Naproxen on Myofascial Pain: A Randomized Double-blind Controlled Trial
In Brief
A Phase 4 clinical trial evaluating naproxen sodium+codeine phosphate, naproxen sodium+dexamethasone, naproxen sodium, paracetamol for Temporomandibular Disorder. Completed, enrolled 200 participants across 1 site.
Detailed Summary
Temporomandibular disorders (TMDs) are one of the most common muco-skeletal disorders, seen in the dental clinics. Many factors work together to initiate or aggravate the condition, so it is a multifactorial disorder. The etiology of TMDs may be a result of parafunctional habits such as clenching and bruxism, acute trauma to the jaw, trauma from hyperextension e.g. after a long dental treatment, joint laxity, psychological distress, occlusal disharmony like presence of high crown or free-end saddle leading to joint instability or systemic diseases such as Rheumatoid arthritis or Osteoarthritis. The aim of this study was to evaluate the effects of naproxen sodium+codeine phosphate, naproxen sodium+dexamethasone, and naproxen sodium on pain in patients complaining from temporomandibular pain.
Study Details
Timeline
Interventions
NSAID, steroid, opioid, paracetamol and combinations of this drugs can be used in temporomandibular disorders.