CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 6,412 enrolled
Drug / intervention
Ticagrelor and Aspirin +1 moredrug
Likely dose
Ticagrelor and Aspirin 180mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04078737
NCT04078737Phase 3Completed
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Clopidogrel With Aspirin in High-risk Patients With Acute Non-disabling Cerebrovascular Events II

Beijing Tiantan Hospital·interventional·Posted Sep 6, 2019·Updated Dec 2, 2021

In Brief

A Phase 3 clinical trial evaluating Ticagrelor and Aspirin and Clopidogrel and Aspirin for Stroke and Transient Ischemic Attack. Completed, enrolled 6,412 participants across 214 sites.

Detailed Summary

The primary objective of this trial is to assess the effects of ticagrelor plus aspirin versus clopidogrel plus aspirin on reducing the 3-month risk of any stroke (both ischemic and hemorrhagic, primary outcome) when initiated within 24 hours of symptom onset in CYP2Y19 LOF alleles carriers with TIA or minor stroke.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsStroke, Transient Ischemic Attack
CountriesChina
CollaboratorsMinistry of Science and Technology of the People´s Republic of China

Timeline

Phase 3CompletedFinished
2020202120222023202420252026
First PostedSep 6, 2019
Enrollment StartSep 23, 2019
Primary CompletionJun 24, 2021
Study CompletionJul 1, 2021
TodayJul 2, 2026
Enrollment to primary: 1.8 yearsPosted 6.8 years ago

Interventions

Ticagrelor and Aspirindrug

Day of randomization: Day1:Ticagrelor 180mg; placebo of clopidogrel 300mg; aspirin 75-300mg (open label) Day2-21st: Ticagrelor 90mg bid/day; placebo of clopidogrel 75mg; aspirin 75mg (open label) Day 22nd-3 months:Ticagrelor 90mg bid/day; placebo of clopidogrel 75mg

Clopidogrel and Aspirindrug

Day of randomization: Day 1: Clopidogrel 300mg; placebo of ticagrelor 180mg; aspirin 75-300mg (open label) Day2-21st: Clopidogrel 75mg/day; placebo of ticagrelor 90mg bid/day; aspirin 75mg (open label) Day 22nd-3 months:Clopidogrel 75mg; placebo of ticagrelor 90mg bid/day