CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 60 enrolled
Drug / intervention
Liposomal Bupivacaine Peri-articular Injection +1 moreprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04086186
NCT04086186Phase 4Completed
CompareCT.gov

Clinical Outcomes of an Adductor Canal Block Versus Liposomal Bupivacaine in Total Knee Arthroplasty Patients: A Randomized Prospective Study

Good Samaritan Regional Medical Center, Oregon·interventional·Posted Sep 11, 2019·Updated Sep 11, 2019

In Brief

A Phase 4 clinical trial evaluating Liposomal Bupivacaine Peri-articular Injection and Adductor canal block for Total Knee Arthroplasty and Post-operative Pain Control. Completed, enrolled 60 participants across 1 site.

Detailed Summary

This is a randomized prospective study of 60 patients undergoing total knee arthroplasty evaluating the clinical outcomes of liposomal bupivacaine periarticular injections (PAI) when compared to single shot adductor canal block using bupivacaine HCl.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsTotal Knee Arthroplasty, Post-operative Pain Control
CountriesUnited States
Collaborators--

Timeline

Phase 4CompletedFinished
2017201820192020202120222023202420252026
First PostedSep 11, 2019
Enrollment StartMar 22, 2017
Primary CompletionNov 25, 2018
Study CompletionDec 18, 2018
TodayJul 2, 2026
Enrollment to primary: 1.7 yearsPosted 6.8 years ago

Interventions

Liposomal Bupivacaine Peri-articular Injectionprocedure

A 20mL solution of 266mg of liposomal bupivacaine (Exparel) was mixed with 40mL of normal saline, which was then infiltrated consistently in the posterior capsule, medial and lateral side of the arthrotomy, patella tendon, quadriceps tendon, quadriceps musculature, and subcutaneous soft tissue.

Adductor canal blockprocedure

Anesthesiologist performs preoperative adductor canal block using 15mL of 0.5% Bupivacaine HCl