At a glance
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Effect of Platelet Rich Plasma Injections on Inflammatory and Chondrodegenerative Biomarkers in Patients With Acute Anterior Cruciate Ligament Tears
In Brief
A Phase 2 clinical trial evaluating Experimental Group and Control Group for Anterior Cruciate Ligament Tear and Anterior Cruciate Ligament Rupture. Completed, enrolled 24 participants across 1 site.
Detailed Summary
A potential long-term consequence of anterior cruciate ligament injuries is the development of post-traumatic osteoarthritis in the years following injury. There are no curative treatments for osteoarthritis, increasing the importance of minimizing the occurrence of post-traumatic osteoarthritis following anterior cruciate ligament injuries. Current literature has begun to indicate that biochemical changes in the knee joint cartilage, such as chondrocyte death, following injury can contribute to the development of post-traumatic osteoarthritis. The main objective of this study is to determine if an early intervention of joint aspiration and platelet rich plasma injection will positively affect the biomarkers representative of chondral degeneration in patients with anterior cruciate ligament injuries. We hypothesize that the intervention will reduce the volume of inflammatory and chondrodegenerative biomarkers following anterior cruciate ligament injury.
Study Details
Timeline
Interventions
Patients will receive platelet rich plasma injection two times prior to surgery.
Patients will have their knee aspirated at their initial physician visit and at the time of surgery.