At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Insulin Resistance, Cognitive Health, and Perfusion of the Adolescent Brain
In Brief
A clinical study evaluating Oral Glucose Tolerance Test (OGTT), 3 Tesla MRI, and 2 other interventions for Insulin Resistance. Completed, enrolled 23 participants across 1 site.
Detailed Summary
The growing population of adolescents with insulin resistance (IR) is predicted to create a large public health burden in the next few decades. This study examines the function of brain blood vessels and cognitive function, to test if increasing severity of IR in adolescents is related to reduced cognitive function and reduced brain blood vessel function. Findings from this study may help create treatments to delay or prevent some of the negative effects of IR on cognitive and vascular health.
Study Details
Timeline
Interventions
Eligible subjects will undergo MRI scanning before and after oral glucose tolerance test.
A 3 Tesla MRI will be used to assess brain structure, quantify cerebral blood flow and capture cerebral vessel structure at designated time points throughout the study visits.
A blood sampling IV catheter will be used to draw blood samples at specific time points throughout each study visit to measure concentrations of glucose and insulin.
A battery of cognitive tests will be completed by the subject.