At a glance
ClinicalIndex Comparison RecordPhase 3Completed· 900 enrolled
Drug / intervention
IV acetaminophen +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
PANDORA: Scheduled Prophylactic 6-hourly Intravenous Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients
In Brief
A Phase 3 clinical trial evaluating IV acetaminophen and Placebo for Delirium in Old Age and 2 related conditions. Completed, enrolled 900 participants across 10 sites.
Detailed Summary
Our objective is to find an effective prophylactic intervention by evaluating IV acetaminophen's impact in reducing the frequency of postoperative delirium, one of the most common and detrimental complications of cardiac surgery in older adults.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDelirium in Old Age, Delirium, Coronary Artery Disease
CountriesUnited States
CollaboratorsNational Institute on Aging (NIA)
Timeline
Phase 3CompletedFinished
2020202120222023202420252026
First PostedSep 2019
Enrollment StartAug 2020
Primary CompletionMar 2026
Study CompletionApr 2026
TodayJul 2026
First PostedSep 17, 2019
Enrollment StartAug 11, 2020
Primary CompletionMar 30, 2026
Study CompletionApr 5, 2026
TodayJul 2, 2026
Enrollment to primary: 5.6 yearsPosted 6.8 years ago
Interventions
IV acetaminophendrug
use of IV tylenol for pain
Placeboother
Volume of the placebo (saline) will match that of IV acetaminophen at 100ml 0.9% NaCl