CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 146 enrolled
Drug / intervention
CLE-100 +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04103892
NCT04103892Phase 2Completed

A Two-Part Study of CLE-100 as an Adjunct Therapy in Subjects With Major Depressive Disorder

Clexio Biosciences Ltd.·interventional·Posted Sep 26, 2019·Updated Oct 14, 2025

In Brief

A Phase 2 clinical trial evaluating CLE-100 and placebo for Adjunctive Treatment of Major Depressive Disorder. Completed, enrolled 146 participants across 46 sites in 2 countries.

Detailed Summary

The clinical trial is a Phase 2, double-blind, randomized, placebo controlled study in Major Depressive Disorder (MDD) participants currently treated with antidepressant therapy. The objective of the study is to assess CLE-100 for the treatment of MDD in participants currently treated with standard antidepressant therapy.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesPuerto Rico, United States
Collaborators--

Timeline

Phase 2CompletedFinished
2020202120222023202420252026
First PostedSep 26, 2019
Enrollment StartSep 5, 2019
Primary CompletionSep 21, 2022
Study CompletionOct 5, 2022
TodayJul 2, 2026
Enrollment to primary: 3.0 yearsPosted 6.8 years ago

Interventions

CLE-100drug

1 tablet of CLE-100 administered once daily

placebodrug

1 tablet of placebo administered once daily