At a glance
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Effects of Penehyclidine on Postoperative Nausea and Vomiting in Patients Underging Bimaxillary Surgery: A Retrospective Cohort Study
In Brief
An observational study evaluating Penehyclidine hydrochloride and No penehyclidine hydrochloride for Penehyclidine and 2 related conditions. Completed, enrolled 243 participants across 2 sites.
Detailed Summary
Postoperative nausea and vomiting (PONV) are common complications after surgery. Patients undergoing orthognathic surgery are reported to have a high rate of PONV, especially those undergoing bimaxillary surgery. Activation of cholinergic system plays an important role in the development of PONV. Penehyclidine is an muscarinic antagonists which selectively block M1 and M3 receptors and is commonly used to decrease oral secretion. The purpose of this retrospective cohort study is to investigate whether use of penehyclidine is associated with a reduced risk of PONV in patients undergoing bimaxillary surgery.
Study Details
Timeline
Interventions
Penehyclidine hydrochloride was administered before anesthesia induction.
Penehyclidine hydrochloride was not administered before anesthesia induction.