CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 80 enrolled
Drug / intervention
Barium concentration +2 morecombination
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04114617
NCT04114617N/ACompleted

Physiological Flow of Liquids in Healthy Swallowing

University Health Network, Toronto·observational·Posted Oct 3, 2019·Updated Dec 21, 2022

In Brief

An observational study evaluating Starch-thickened liquids, Xanthan-gum thickened liquids, and 1 other intervention for Deglutition and 2 related conditions. Completed, enrolled 80 participants across 1 site.

Detailed Summary

Thickened liquids are commonly used as an intervention for people with dysphagia (swallowing impairment). However, the field currently lacks a proper understanding of how this intervention works. The overall goal of the project is to collect measurements of bolus flow through the oropharynx (i.e., mouth and throat) during swallowing. The factors that are expected to influence bolus flow include the liquid/food consistency (i.e., thin, slightly-thick, mildly-thick, moderately-thick, extremely thick, solid) and the forces applied during swallowing (i.e., tongue pressures and swallowing muscle contraction). The objective is to determine how these factors interact to influence the flow of a bolus through the oropharynx in healthy swallowing.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
CountriesCanada

Timeline

N/ACompletedFinished
20162017201820192020202120222023202420252026
First PostedOct 3, 2019
Enrollment StartJan 1, 2016
Primary CompletionSep 12, 2019
Study CompletionDec 31, 2020
TodayJul 2, 2026
Enrollment to primary: 3.7 yearsPosted 6.7 years ago

Interventions

Starch-thickened liquidsother

Thickener added in amounts required to reach slightly thick, mildly thick, moderately thick and extremely thick consistencies, as defined by the International Dysphagia Diet Standardisation Initiative flow test.

Xanthan-gum thickened liquidsother

Thickener added in amounts required to reach slightly thick, mildly thick, moderately thick and extremely thick consistencies, as defined by the International Dysphagia Diet Standardisation Initiative flow test.

Barium concentrationcombination

Commercially available barium products diluted to different concentrations (i.e., 20% w/v, 40% w/v) through the addition of water